Guy earned his PhD in Pharmacology in 1996 at the University of Sherbrooke in Sherbrooke, Canada. In 1997, Guy joined Henry R. Bourne’s laboratory at the University of California San Francisco as a post-doctoral fellow. There he made several seminal discoveries on signaling mechanisms regulating GPCR-induced leukocyte chemotaxis, showing that PI-3-Kinase activity plays a pivotal role in the establishment of cell polarity and publishing his results in internationally recognized journals such as Science, Nature Cell Biology, Trends in Cell Biology and Molecular Biology of the Cell. In September 2000 he joined Senomyx as a Scientist and was rapidly promoted through the ranks becoming Senior Director of Assay Development and High Throughput Screening in January 2010. In 2007, Guy’s team discovered the first sweet taste enhancer ever described. Results from this discovery were recently published in Proceedings of the National Academy of Sciences. This significant initial breakthrough subsequently led the development of potent sucralose and sucrose enhancers that will be entering the market in 2011.