ACAD
34.33
+0.5
+1.48%
AEMD
2.23
-0.04
-1.76%
APRI
1.13
+0.02
+1.80%
ARNA
1.34
-0.04
-2.90%
ATEC
2.03
-0.1
-4.69%
CNAT
8.36
-0.41
-4.68%
CRXM
0.195
+0.012
+6.47541%
CYTX
1.03
-0.04
-3.74%
DXCM
77.96
+0.03
+0.04%
GNMK
12.82
-0.06
-0.47%
HALO
13.94
-0.05
-0.36%
ILMN
184.86
+1.12
+0.61%
INNV
0.09
0.00
-1.10%
INO
6.29
-0.14
-2.18%
ISCO
1.75
+0.08
+4.48%
ISIS
57.56
0.00
0.00%
LGND
111.17
-0.02
-0.02%
LPTN
2.93
-0.08
-2.66%
MBVX
2.27
+0.06
+2.71%
MEIP
1.59
0.00
0.00%
MNOV
5.75
-0.07
-1.20%
MRTX
4.55
-0.22
-4.71%
MSTX
0.131
-0.007
-5.278%
NBIX
53.4
-0.19
-0.35%
NUVA
72.51
-0.3
-0.41%
ONCS
1.15
+0.01
+0.88%
ONVO
2.9
+0.01
+0.35%
OREX
3.37
-0.24
-6.65%
OTIC
13.35
-0.3
-2.20%
QDEL
24.17
+0.02
+0.08%
RCPT
231.96
0.00
0.00%
RGLS
1.55
-0.05
-3.13%
RMD
67.99
-4.86
-6.67%
SPHS
2.578
+0.028
+1.0863%
SRNE
1.95
-0.15
-7.14%
TROV
0.93
+0.02
+2.46%
VICL
2.36
+0.05
+2.16%
VOLC
18
0.00
0.00%
ZGNX
11
0.00
0.00%
ACAD
34.33
+0.5
+1.48%
AEMD
2.23
-0.04
-1.76%
APRI
1.13
+0.02
+1.80%
ARNA
1.34
-0.04
-2.90%
ATEC
2.03
-0.1
-4.69%
CNAT
8.36
-0.41
-4.68%
CRXM
0.195
+0.012
+6.47541%
CYTX
1.03
-0.04
-3.74%
DXCM
77.96
+0.03
+0.04%
GNMK
12.82
-0.06
-0.47%
HALO
13.94
-0.05
-0.36%
ILMN
184.86
+1.12
+0.61%
INNV
0.09
0.00
-1.10%
INO
6.29
-0.14
-2.18%
ISCO
1.75
+0.08
+4.48%
ISIS
57.56
0.00
0.00%
LGND
111.17
-0.02
-0.02%
LPTN
2.93
-0.08
-2.66%
MBVX
2.27
+0.06
+2.71%
MEIP
1.59
0.00
0.00%
MNOV
5.75
-0.07
-1.20%
MRTX
4.55
-0.22
-4.71%
MSTX
0.131
-0.007
-5.278%
NBIX
53.4
-0.19
-0.35%
NUVA
72.51
-0.3
-0.41%
ONCS
1.15
+0.01
+0.88%
ONVO
2.9
+0.01
+0.35%
OREX
3.37
-0.24
-6.65%
OTIC
13.35
-0.3
-2.20%
QDEL
24.17
+0.02
+0.08%
RCPT
231.96
0.00
0.00%
RGLS
1.55
-0.05
-3.13%
RMD
67.99
-4.86
-6.67%
SPHS
2.578
+0.028
+1.0863%
SRNE
1.95
-0.15
-7.14%
TROV
0.93
+0.02
+2.46%
VICL
2.36
+0.05
+2.16%
VOLC
18
0.00
0.00%
ZGNX
11
0.00
0.00%
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Study in Nature Shows Early Relapse Detection in Lung Cancer Using Natera’s Technology for ctDNA Analysis

April 26, 2017 – 9:26 am

Relapse detected up to 347 days earlier than standard of care, with sensitivity and specificity exceeding 90%

SAN CARLOS, Calif. and LONDON, April 26, 2017 /PRNewswire/ — Natera, Inc., (NASDAQ: NTRA), a leader in non-invasive genetic testing, and Cancer Research UK, University College of London (UCL) Cancer Institute and the Francis Crick Institute today announced the publication of results from the first 100 patients in the Cancer Research UK-funded TRACERx study (Tracking Cancer Evolution Through Therapy [Rx]) by Nature. This is the first demonstration of using phylogenetic circulating tumor DNA (ctDNA) analysis to detect relapse and minimally residual disease in patients with early-stage non-small cell lung cancer (NSCLC). The study indicates that it is now feasible to use Natera’s bespoke multiplex PCR technology to conduct clinical studies in NSCLC to identify and treat residual disease, define treatment response, and target emerging subclones prior to resistance. The manuscript, entitled “Phylogenetic circulating tumor DNA analysis depicts early stage lung cancer evolution”, is available online on April 26, 2017 from Nature as an Accelerated Article Preview (AAP).1

“We are pleased with the groundbreaking results of this two-year Cancer Research UK-funded collaboration with the TRACERx consortium, University College of London (UCL) Cancer Institute, and the Francis Crick Institute,” said Natera CEO and founder, Matthew Rabinowitz, Ph.D. “We are working towards bringing this technology to market later this year, initially to serve researchers in academia and the pharmaceutical industry, and ultimately to save lives in the clinic by enabling earlier diagnosis and personalized treatment of disease.”

TRACERx Study Highlights

In the TRACERx study, led by Principal Investigator Prof. Dr. Charles Swanton, bespoke personalized assays were developed by Natera to target variants selected after sequencing of primary tumors. Patients were followed after surgery with blood drawn every 3-6 months, and ctDNA measurements were used to track clonal and subclonal evolution of the disease. Natera’s unique multiplexing capability allowed it to design and analyze over 20 PCR assays for each specimen, without splitting any plasma samples; this unique ability was critical for tracking multiple subclones simultaneously.

A subset of 24 patients were studied for detection of cancer relapse. Presence of circulating tumor DNA was successfully detected in 93% (13/14) of patients at or prior to relapse, up to 347 days earlier than standard of care. Test specificity was [90%] in a control group of 10 patients who remained relapse-free at the time of publication.

Results also showed the ability to predict treatment response in the adjuvant setting. For one patient in whom ctDNA levels were high just 48 hours after surgery, ctDNA shrank to zero after adjuvant chemotherapy and the patient remained disease-free at the time of publication. By contrast, for three patients in whom ctDNA levels remained high throughout adjuvant therapy, all three patients recurred within one year after surgery. This indicates the potential of phylogenetic ctDNA analysis to improve the benefits of adjuvant chemotherapy for NSCLC patients in the clinic by enabling earlier recurrence diagnosis and personalized treatment of disease.

“The next step is to pursue Phase III clinical studies, where therapeutic intervention can be started earlier based on diagnosis of molecular relapse in circulating tumor DNA, and where therapy can be directed to the evolving tumor subclone seeding metastatic recurrence,” said Charles Swanton, M.D., Ph.D., of the Translational Cancer Therapeutics Laboratory at The Francis Crick Institute in London, and senior researcher and author of the study.

About TRACERx

The TRACERx (TRAcking Cancer Evolution through therapy (Rx)) lung study is a multi-million-pound research project taking place over nine years, aimed at transforming understanding of non-small cell lung cancer and taking a practical step towards an era of precision medicine. The goal of the study is to uncover mechanisms of cancer evolution by analyzing the intratumor heterogeneity in lung tumors from approximately 850 patients and tracking its evolutionary trajectory from diagnosis through to relapse. At £14 million, it’s the biggest single investment in lung cancer research by Cancer Research UK, and the start of a strategic UK-wide focus on the disease, aimed at making real progress for patients. Led by Professor Charles Swanton at University College London (UCL), the study will bring together a network of experts from different disciplines to help integrate clinical and genomic data and identify patients who could benefit from trials of new, targeted treatments. Natera’s technology was selected to provide unprecedented insight into the genomic landscape of primary and metastatic tumors and the impact of treatment upon this landscape. For more information, go to http://www.cruklungcentre.org/Research/TRACERx.

About Natera’s Oncology Program

Natera’s mPCR technology and proprietary algorithms for oncology applications were developed in the context of non-invasive prenatal testing (NIPT), which can identify Down syndrome and other chromosomal aneuploidies and microdeletions with high accuracy. Natera has enhanced this underlying technology for the oncology market, and believes that it has powerful tools for the early identification of cancer and for recurrence monitoring. The company plans to launch its first oncology testing services in late 2017 for research use only, based on the bespoke mPCR technology demonstrated in the TRACERx study.

About Natera
Natera is a genetic testing company that develops and commercializes non-invasive methods for analyzing DNA. The mission of the company is to transform the diagnosis and management of genetic disease. In pursuit of that mission, Natera operates a CAP-accredited laboratory certified under the Clinical Laboratory Improvement Amendments (CLIA) in San Carlos, CA, and it currently offers a host of proprietary genetic testing services primarily to OB/GYN physicians and fertility centers, as well as to genetic laboratories through its cloud-based Constellation™ software system.

Product offerings include the Spectrum® pre-implantation genetic test for embryo selection during IVF; the Anora® miscarriage test to understand the genetic causes of a pregnancy loss; the Horizon™ carrier test to detect inherited mutations; the Panorama® non-invasive prenatal test (NIPT) to identify common chromosomal anomalies in a fetus as early as nine weeks of gestation; and Evercord™, a cord blood and tissue banking service offered at birth to expectant parents. Each test described has been developed and its performance characteristics determined by the CLIA-certified laboratory performing the test.

These tests have not been cleared or approved by the U.S. Food and Drug Administration (FDA). Although FDA does not currently clear or approve laboratory-developed tests in the U.S., certification of the laboratory is required under CLIA to ensure the quality and validity of the tests. Natera is also applying its unique technologies to develop non-invasive screening and diagnostic tools for earlier detection and improved treatment of cancer. These tests have not been cleared or approved by the U.S. Food and Drug Administration.

Forward-looking statements

This release contains forward-looking statements. All statements other than statements of historical facts contained in this press release are forward-looking statements. Any forward-looking statements contained in this press release are based upon Natera’s historical performance and its current plans, estimates, and expectations, and are not a representation that such plans, estimates, or expectations will be achieved. These forward-looking statements represent Natera’s expectations as of the date of this press release.

Subsequent events may cause these expectations to change, and Natera disclaims any obligation to update the forward-looking statements for any reason after the date of this press release.

These forward-looking statements are subject to a number of known and unknown risks and uncertainties that may cause actual results to differ materially, including with respect to our efforts to develop and commercialize new product offerings, our ability to successfully increase demand for and grow revenues for our product offerings, whether the results of clinical studies will support the use of our product offerings, our expectations of the reliability, accuracy and performance of our screening tests, or of the benefits of our screening tests and product offerings to patients, providers and payers.

Additional risks and uncertainties are discussed in greater detail in the sections entitled “Risk Factors” and “Management’s Discussion and Analysis of Financial Condition and Results of Operations” in Natera’s Form 10-K for the year ended December 31, 2016. Further information on potential risks that could affect actual results will be included in other filings Natera makes with the SEC from time to time. These documents are available for free on the company’s website at www.natera.com in the Investor Relations section, and on the SEC’s website at www.sec.gov.

1Journal Reference: Abbosh, C., Birkbak, N, J., Wilson, G, A., et al. Phylogenetic ctDNA analysis depicts early stage lung cancer evolution. Nature. DOI: 10.1038/nature22364

Contacts: Natera, Inc.

Mike Brophy, Chief Financial Officer, 650-249-9091 x1471

mbrophy@natera.com

Laura Zobkiw, Corporate and Media Relations, 650-249-9091 x1649

Lzobkiw@natera.com

Contacts: Cancer Research UK

Kathryn Ingham, +44(0)2034695475, (outside-of-office-hours): +44(0)7050264059

Kathryn.ingham@cancer.org.uk

 

SOURCE Natera, Inc.

Biocompare, Inc. Launches the Trends in Biopharmaceutical Analysis Future Lab

April 26, 2017 – 9:00 am

SOUTH SAN FRANCISCO, Calif., April 26, 2017 /PRNewswire/ — Biocompare, a Division of CompareNetworks, Inc. and the leading product information resource for the life sciences, has launched the seventh in an ongoing series of digital immersive platforms called Future Lab: Trends in Biopharmaceutical Analysis (http://www.biocompare.com/Future-Lab/Biopharmaceutical-Analysis/). This interactive content hub, sponsored by Agilent was created to share the latest advances, trends, and applications in the analysis of complex biotherapeutics. In this Future Lab, researchers will learn about the appropriate tools and techniques needed to characterize biologic products, the importance of post-translational modifications, and how to overcome challenges associated with characterization of mAbs and therapeutic proteins.

There has been a positive response to these content hubs; in 2016 Biocompare launched four other Future Labs. The first Future Lab focused on Protein Production. Sponsored by Bio-Rad this hub focused on content targeted to scientists that are involved in all aspects of this process, from basic research through therapeutic protein production. The second Future Lab was specific to Immunodetection. Sponsored by Bio-Techne the Immunodetection Future Lab featured information on various aspects of antibody based applications. The third Future Lab was on maintaining a cell culture facility sponsored by NuAire. The fourth Future Lab was on Flow Cytometry sponsored by Thermo. The fifth Future Lab was on Liquid Handling sponsored by Gilson. The most recent Future Lab was sponsored by Roche and focuses on Trends in Next-Gen Sequencing.   

“We are really excited to have developed this platform to allow the 3 million scientists who visit Biocompare each year to be able to consume content in a much more engaging environment. This fully supports Biocompare’s mission to educate scientists in the latest technology while providing the tool provider community a unique and novel way to engage with our audience,” says Joan Boyce, VP & GM of Biocompare.

Future Lab brings together topical content and presents it in a focused and interactive environment to keep readers informed of the latest developments in research. The benefit of this is that as content gets added, users will be notified and come back over time to consume content. With all the available resources out there to users, it’s the best way to push out content and see an immediate response.

“The creation of Future Lab is the next phase of growth and content development for Biocompare and we’re excited about launching additional Future Labs in areas that are driving basic and translational research,” says Mike Okimoto, Ph.D., Biocompare’s co-founder and Chief Content Officer. “The next iteration of the platform will provide additional engagement opportunities and we look forward to rolling them out in the coming months.”

Creating a community through content is what keeps users engaged and will in turn bring the scientific community closer.

About Biocompare

Biocompare, a Division of CompareNetworks, Inc. is the leading resource for up-to-date product information, product reviews, and new technologies for life scientists. Biocompare combines in-depth knowledge of the life science products and new technologies with the power of the Internet to offer scientists the most dynamic, relevant, and innovative media-based marketplace for life science information. Produced by scientists, Biocompare’s mission is to provide free, time saving services to life science researchers, allowing scientists to find and learn about the technologies that drive discovery. Biocompare continually strives to serve the life science community by providing new and improved online services that facilitate product discovery and technology education. For more information, please visit www.biocompare.com.

 

 

SOURCE Biocompare

BioPharmX Announces $5.0 Million Offering

April 26, 2017 – 5:00 am

MENLO PARK, Calif., April 26, 2017 /PRNewswire/ — BioPharmX Corporation (NYSE MKT: BPMX), a specialty pharmaceutical company developing products for the dermatology market, announced that it is has entered into securities purchase agreements with certain existing institutional investors for the purchase and sale of 6,410,258 shares of common stock at a price of $0.78 per share with 50% warrant coverage (representing warrants to purchase up to 3,205,129 shares of common stock) in a registered direct offering.  The warrants will be exercisable at an exercise price of $0.90 per share beginning six months following the closing date and will expire five years from the date they become exercisable.  The gross proceeds of the offering are expected to be approximately $5.0 million.  

Net proceeds of the offering will be used to advance the BioPharmX dermatology-focused drug delivery and clinical programs, including advancing the company’s lead product BPX-01, and general corporate purposes.

The offering is expected to close on April 28, 2017, subject to customary closing conditions.

Roth Capital Partners acted as sole placement agent.

The shares of common stock, warrants, and shares issuable upon exercise of the warrants were offered by BioPharmX pursuant to a shelf registration statement on Form S-3 (File No. 333-209026) which was declared effective by the Securities and Exchange Commission (SEC) on February 4, 2016. A prospectus supplement relating to the offering will be filed with the SEC.

This press release shall not constitute an offer to sell or the solicitation of an offer to buy any of the securities described herein, nor shall there be any sale of these securities in any state or jurisdiction in which such offer, solicitation or sale would be unlawful prior to registration or qualification under the securities laws of any such state or jurisdiction. When available, copies of the prospectus supplement and accompanying base prospectus relating to this offering may be obtained from Roth Capital Partners, 888 San Clemente Drive, Suite 400, Newport Beach, CA 92660, (800) 678-9147 or by accessing the SEC’s website, www.sec.gov.

About BioPharmX® Corporation
BioPharmX Corporation (NYSE MKT: BPMX) is a Silicon Valley-based specialty pharmaceutical company that seeks to provide products through proprietary platform technologies for prescription, over-the-counter and supplement applications in dermatology and women’s health. To learn more about BioPharmX, visit www.BioPharmX.com.    

Forward-Looking Statement
The information in this press release contains forward-looking statements and information within the meaning of Section 27A of the Securities Act of 1933, as amended, and Section 21E of the Securities Exchange Act of 1934, as amended, which are subject to the “safe harbor” created by those sections. This press release contains forward-looking statements about the company’s expectations, plans, intentions and strategies, including, but not limited to, our ability to close the offering, the gross proceeds from the offering, and our intended use of the proceeds from the offering. These forward-looking statements may be identified by words such as “may”, “plan”, “expect,” “anticipate,” “believe,” or similar expressions that are intended to identify such forward-looking statements. These forward-looking statements involve risks and uncertainties, as well as assumptions, which, if they do not fully materialize or prove incorrect, could cause our results to differ materially from those expressed or implied by such forward-looking statements. The risks and uncertainties include those described in the company’s filings with the Securities and Exchange Commission. Given these risks and uncertainties, you are cautioned not to place undue reliance on such forward-looking statements. The forward-looking statements included in this news release are made only as of the date hereof and the company undertakes no obligation to publicly update or revise any forward-looking statements, whether as a result of new information, future events or otherwise, except as may be required under applicable securities laws.

BioPharmX is a registered trademark of BioPharmX, Inc.

 

SOURCE BioPharmX Corporation

Veracyte Announces Multiple Studies Demonstrating Powerful Results from Afirma® Classifiers To Be Presented at the AACE 2017 Annual Meeting

April 26, 2017 – 4:00 am

Data from pivotal clinical validation study for Veracyte’s next-generation Afirma Genomic Sequencing Classifier to be unveiled

SOUTH SAN FRANCISCO, Calif., April 26, 2017 /PRNewswire/ — Veracyte, Inc. (NASDAQ: VCYT), a genomic diagnostics company focused on reducing unnecessary surgeries and healthcare costs by resolving diagnostic uncertainty, today announced that new data demonstrating the strong performance of the Afirma Gene Expression Classifier (GEC) in thyroid cancer diagnosis and its long-term impact on patient care will be presented at the AACE 26th Annual Scientific and Clinical Congress, the annual meeting of the American Association of Clinical Endocrinologists. In addition, researchers will share data validating the company’s next-generation Afirma test, the Afirma Genomic Sequencing Classifier (GSC), at the meeting being held May 3-7 in Austin, Texas.

“Data from the long-term clinical utility studies to be presented at the AACE annual meeting will add to the growing body of evidence reinforcing the Afirma GEC’s value and role as a new standard of care in thyroid cancer diagnosis,” said Bonnie Anderson, Veracyte’s chief executive officer and chairman of the board. “We are also excited to share pivotal clinical validation data demonstrating that the Afirma GSC, our next-generation Afirma test, will enable even more patients to avoid unnecessary surgery as part of thyroid nodule evaluation and diagnosis.”

The following Afirma abstracts will be presented during AACE 2017:

Title:                

Reduced Surgery Through Afirma GEC Impact to Date and Potential for the Future
(Abstract #1065; poster presentation)

Presenter:        

R. Harrell, M.D., Memorial Health System

Date/Time:       

Friday, May 5, 5:00-6:15 p.m. CDT

Title:                

Six-Year Clinical and Imaging Follow Up of an Office-Based Gene Expression Classifier
Used to Manage Thyroid Nodules (Abstract #1067; oral presentation)

Presenter:        

Brian Michael, M.D., Wellspan Health

Date/Time:       

Saturday, May 6, 9:15-10:00 a.m. CDT

Title:                

A Next-Generation Gene Expression Classifier for Cytologically Indeterminate Thyroid
Nodules Derived From a Novel Sequencing Platform and Machine Learning Algorithms
with Improved Clinical Specificity: Interim Analysis (Abstract #1121; poster presentation)

Presenter:        

Paul Ladenson, M.D., Johns Hopkins University School of Medicine

Date/Time:       

Saturday, May 6, 10:00-11:00 a.m. CDT

In addition to performance data generated in the development of the Afirma GSC, which will be presented on Saturday (Poster #1121), researchers will share data from the pivotal clinical validation study for the next-generation classifier in a Veracyte Product Theater. This event will take place Thursday, May 4, from 1:15-2:00 p.m. CDT in Product Theater A.

About the Afirma GEC
The Afirma GEC is used to identify patients with benign thyroid nodules among those with indeterminate cytopathology results in order to preserve the thyroid. Each year in the United States, more than 525,000 fine needle aspiration biopsies are performed to assess patients with potentially cancerous thyroid nodules. Up to 30 percent of the results are indeterminate (not clearly benign or malignant) and physicians have traditionally recommended thyroid surgery for a more definitive diagnosis. Following surgery, however, 70 to 80 percent of patients’ nodules are diagnosed as benign, meaning the surgery was unnecessary. Such surgery is invasive, costly and often leads to the need for lifelong daily thyroid hormone replacement drugs.

About Veracyte
Veracyte (NASDAQ: VCYT) is a leading genomic diagnostics company that is fundamentally improving patient care by resolving diagnostic uncertainty with evidence that is trustworthy and actionable. The company’s products uniquely combine genomic technology, clinical science and machine learning to provide answers that give physicians and patients a clear path forward without risky, costly surgery that is often unnecessary. Since its founding in 2008, Veracyte has commercialized three genomic tests, which are transforming the diagnosis of thyroid cancer, lung cancer and idiopathic pulmonary fibrosis and collectively target a $2 billion market opportunity. Veracyte is based in South San Francisco, California. For more information, please visit www.veracyte.com and follow the company on Twitter (@veracyte).

Cautionary Note Regarding Forward-Looking Statements 
This press release contains “forward-looking statements” within the meaning of the Private Securities Litigation Reform Act of 1995. Forward-looking statements can be identified by words such as: “anticipate,” “intend,” “plan,” “expect,” “believe,” “should,” “may,” “will” and similar references to future periods. Examples of forward-looking statements include, among others, our ability to successfully scale the company and our belief that we are well positioned for profitable growth. Forward-looking statements are neither historical facts nor assurances of future performance. Instead, they are based only on our current beliefs, expectations and assumptions regarding the future of our business, future plans and strategies, anticipated events and trends, the economy and other future conditions. Forward-looking statements involve risks and uncertainties, which could cause actual results to differ materially, and reported results should not be considered as an indication of future performance. These risks and uncertainties include, but are not limited to: the applicability of clinical results to actual outcomes; laws and regulations applicable to our business, including potential regulation by the Food and Drug Administration or other regulatory bodies; the size of the market opportunity for our products; our ability to successfully achieve adoption of and reimbursement for our products; the amount by which use of our products are able to reduce invasive procedures and misdiagnosis, and reduce healthcare costs; the occurrence and outcomes of clinical studies; the timing and publication of clinical study results; and other risks set forth in the company’s filings with the Securities and Exchange Commission, including the risks set forth in the company’s Annual Report on Form 10-K for the year ended December 31, 2016. These forward-looking statements speak only as of the date hereof and Veracyte specifically disclaims any obligation to update these forward-looking statements.

Veracyte, Afirma, Percepta, Envisia, the Veracyte logo, and the Afirma logo are trademarks of Veracyte, Inc.

 

SOURCE Veracyte

Trovagene to Announce First Quarter 2017 Financial Results and Host Conference Call on Wednesday, May 10, 2017

April 26, 2017 – 4:00 am

SAN DIEGO, April 26, 2017 /PRNewswire/ — Trovagene, Inc. (NASDAQ: TROV), a precision medicine biotechnology company, announced today that it will report financial results for the first quarter ended March 31, 2017 on Wednesday, May 10, 2017.

Trovagene’s senior management team will host a conference call on Wednesday, May 10, 2017 at 5:00 p.m. Eastern Daylight Time (2:00 p.m. Pacific Daylight Time) to discuss the results and update investors on the Company’s progress.

To access the conference call, please dial (888) 347-6081 (domestic), (412) 902-4285 (international), or (855) 669-9657 (Canada), conference ID# 10097532. To access the telephone replay of the call, dial (877) 344-7529 (domestic), (412) 317-0088 (international), or (855) 669-9658 (Canada), replay ID# 10105678. The replay will be available one hour after the conclusion of the call. The webcast and telephone replay will be archived on the Company’s website following the conference at http://trovagene.investorroom.com/events.  

About Trovagene, Inc.

Trovagene is a precision medicine biotechnology company developing oncology therapeutics for improved cancer care by leveraging its proprietary Precision Cancer Monitoring® (PCM) technology in tumor genomics.  Trovagene has broad intellectual property and proprietary technology to measure circulating tumor DNA (ctDNA) in urine and blood to identify and quantify clinically actionable markers for predicting response to cancer therapies.  Trovagene offers its PCM technology at its CLIA/CAP – accredited laboratory and plans to continue to vertically integrate its PCM technology with precision cancer therapeutics.  For more information, please visit www.trovagene.com.

Trovagene Contact:

Vicki Kelemen
Sr. Director, Communications
858-952-7652
vkelemen@trovagene.com

 

SOURCE Trovagene, Inc.

Orexigen Therapeutics to Provide Business Update and Discuss First Quarter 2017 Financial Results on May 9, 2017

April 25, 2017 – 2:05 pm

SAN DIEGO, April 25, 2017 /PRNewswire/ — Orexigen Therapeutics, Inc. (NASDAQ: OREX) will announce corporate and financial results for the first quarter 2017 on Tuesday, May 9th after the market closes. Following the announcement, Orexigen will provide a business update and discuss the financial results in a live webcast and conference call at 5:00 p.m. Eastern Daylight Time (2:00 p.m. Pacific Daylight Time).

The live call may be accessed by phone by calling (800) 708-4540 (domestic) or (847) 619-6397 (international), participant code 44748374. The webcast can be accessed live on the “Investors” section of the Orexigen web site at www.orexigen.com, and will be archived for 14 days following the call.

Orexigen Contact:

Jason Keyes
Chief Financial Officer
Orexigen Therapeutics, Inc.
+1-858-875-8600
jkeyes@orexigen.com

Media Contact:
Erika Hackmann
Y&R
+1-917-538-3375
erika.hackmann@yr.com

 

SOURCE Orexigen Therapeutics, Inc.

Neurocrine Announces Proposed Convertible Senior Notes Offering

April 25, 2017 – 12:01 pm

SAN DIEGO, April 25, 2017 /PRNewswire/ — Neurocrine Biosciences, Inc. (NASDAQ: NBIX) today announced its intention to offer, subject to market and other conditions, $450.0 million aggregate principal amount of convertible senior notes due 2024 (the “notes”) in a private offering to qualified institutional buyers pursuant to Rule 144A under the Securities Act of 1933, as amended (the “Securities Act”). Neurocrine also expects to grant the initial purchasers of the notes a 30-day option to purchase up to an additional $67.5 million aggregate principal amount of notes. 

The notes will be senior unsecured obligations of Neurocrine and will accrue interest payable semiannually in arrears. The notes will be convertible in certain circumstances into cash, shares of Neurocrine’s common stock, or a combination of cash and shares of Neurocrine’s common stock, at Neurocrine’s election. The interest rate, initial conversion rate and other terms of the notes will be determined at the time of the pricing of the offering.

Neurocrine intends to use the net proceeds from the offering for general corporate purposes, which may include commercialization expenses, clinical trial and other research and development expenses, capital expenditures, working capital and general and administrative expenses.

The offer and sale of the notes and the shares, if any, issuable upon conversion of the notes have not been and will not be registered under the Securities Act or applicable state securities laws, and the notes and such shares may not be offered or sold in the United States absent registration or an applicable exemption from the registration requirements of the Securities Act and applicable state securities laws. This press release shall not constitute an offer to sell or the solicitation of an offer to buy the notes or any shares issuable upon conversion of the notes, nor shall there be any sale of the notes or such shares, in any state or jurisdiction in which such offer, solicitation or sale would be unlawful.

About Neurocrine Biosciences

Neurocrine Biosciences is a San Diego based biotechnology company focused on neurologic, psychiatric and endocrine related disorders. In April of 2017 the FDA approved INGREZZATM (valbenazine) capsules for the treatment of adults with tardive dyskinesia (TD).  INGREZZA is a novel, selective vesicular monoamine transporter 2 (VMAT2) inhibitor, and is the first and only FDA-approved product indicated for the treatment of adults with TD.  The Company markets INGREZZA in the United States. The Company’s three late-stage clinical programs are: elagolix, a gonadotropin-releasing hormone antagonist for women’s health that is partnered with AbbVie Inc.; opicapone, a novel, once-daily, peripherally-acting, highly-selective catechol-o-methyltransferase inhibitor under investigation as adjunct therapy to levodopa in Parkinson’s patients; and INGREZZA™ (valbenazine), a novel, once-daily, selective VMAT2 inhibitor under investigation for the treatment of Tourette Syndrome.

Forward-Looking Statements

In addition to historical facts, this press release contains forward-looking statements that involve a number of risks and uncertainties such as those, among others, relating to Neurocrine’s expectations regarding the completion, timing and size of its proposed offering.  Among the factors that could cause actual results to differ materially from those indicated in the forward-looking statements are risks and uncertainties associated with market conditions, whether Neurocrine will offer the notes or be able to consummate the proposed offering at the anticipated size or on the anticipated terms, or at all, the satisfaction of closing conditions related to the proposed offering, as well as risks and uncertainties associated with Neurocrine’s business and finances in general, and the other risks described in Neurocrine’s annual report on Form 10-K for the year ended December 31, 2016.  Neurocrine undertakes no obligation to update the statements contained in this press release after the date hereof.

 

SOURCE Neurocrine Biosciences, Inc.

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