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SGI-DNA Launches Gibson Assembly® HiFi 1 Step Kit for Simple, Seamless and Rapid Construction of Synthetic Genes, Gene Clusters and Genetic Pathways

November 20, 2014 – 11:00 am | Edit Post

LA JOLLA, Calif., Nov. 20, 2014 /PRNewswire/ — SGI-DNA announces the launch of the Gibson Assembly® HiFi 1 Step Kit which allows researchers to assemble multiple, large DNA fragments in a simple one hour, one-step reaction.

This is the first high fidelity kit on the market using the Gibson Assembly® method.  Researchers can now assemble up to 5 fragments, including large constructs (up to 100 kb), in a fast, reliable reaction.

“With the Gibson Assembly® HiFi 1 Step Kit researchers can obtain a perfect clone in their initial attempt,” says Vibhu Gupta, Senior Product Manager at SGI-DNA. “The kit provides a proprietary enzyme formulation for Gibson Assembly® that results in significantly less errors at cloning junctions which is a common challenge for researchers in a variety of disciplines.”

A researcher from the University of California, San Diego, Erna van Niekerk, PhD., comments, “I have tried it with a construct and ran a parallel experiment with a competing kit from another vendor. I picked 3 colonies from the Gibson Assembly® HiFi 1 Step Kit and 3 colonies from the competing product. Three of 3 Gibson clones gave me the right insert. Zero of 3 from competing kit gave me the right insert. Of the 3 Gibson clones: 2 of 3 had the correct sequence both forward and reverse sequencing confirmation and 1 of 3 had an extra nucleotide.”

The Gibson Assembly® method was developed in 2009 by Dan Gibson, Ph.D., and his colleagues at the J. Craig Venter Institute during the team’s quest to construct the first synthetic cell. It uses a one-step, isothermal approach to enable the rapid assembly of oligonucleotides and multiple DNA fragments. Since its introduction to the life science community, the Gibson Assembly® method has become a mainstay in many synthetic biology laboratories and has attracted interest from both the academic and commercial life sciences community due to its ease-of-use, robustness and flexibility. This Gibson Assembly® kit provides researchers SGI’s first commercially available option utilizing the Gibson Assembly® method. 

The Gibson Assembly® HiFi 1 Step Kit is available in 3 sizes: 5 reactions (starter kit), 10 reactions and 50 reactions.

For more information on the Gibson Assembly® HiFi 1 Step Kit, please visit www.sgidna.com

All products are intended for research use only. Not intended for diagnostic uses.

The Gibson Assembly® method is also available under commercial license. For more information contact us at info@sgidna.com

About SGI-DNA

SGI-DNA, a wholly owned subsidiary of Synthetic Genomics, Inc (SGI), is responsible for all commercial aspects of SGI’s synthetic DNA business and focuses on strategic business relationships with both academic and commercial researchers. Building on the scientific advancements and breakthroughs from leading scientists such as J. Craig Venter, Ham Smith, Clyde Hutchison, Dan Gibson and their teams, SGI-DNA utilizes unique and proprietary DNA technologies to produce complex synthetic genes and reagents. SGI-DNA also offers a comprehensive suite of genomic services, including whole genome sequencing, library design, and other bioinformatics services.

SGI-DNA Technical contact: Vibhu Gupta, Senior Product Manager, 858.433.2288; vgupta@syntheticgenomics.com

Media contact: Heather Kowalski, hkowalski@syntheticgenomics.com; 858-361-0466
SOURCE Synthetic Genomics Inc.

Signaling Molecule Crucial to Stem Cell Reprogramming

November 20, 2014 – 10:54 am | Edit Post

While investigating a rare genetic disorder, researchers at the University of California, San Diego School of Medicine have discovered that a ubiquitous signaling molecule is crucial to cellular reprogramming, a finding with significant implications for stem cell-based regenerative medicine, wound repair therapies and potential cancer treatments.

Signaling Molecule Crucial to Stem Cell Reprogramming

November 20, 2014 – 10:54 am | Edit Post

While investigating a rare genetic disorder, researchers at the University of California, San Diego School of Medicine have discovered that a ubiquitous signaling molecule is crucial to cellular reprogramming, a finding with significant implications for stem cell-based regenerative medicine, wound repair therapies and potential cancer treatments.

Company tackling love handles goes public

November 20, 2014 – 10:05 am | Edit Post

Neothetics, a developer of cosmetic therapies, said it will sell 4.65 million shares at $14 apiece.

Company tackling love handles goes public

November 20, 2014 – 10:05 am | Edit Post

Neothetics, a developer of cosmetic therapies, said it will sell 4.65 million shares at $14 apiece.

UC San Diego’s Brown Briefs Congress on Brain Development, Substance Use in Young

November 20, 2014 – 7:00 am | Edit Post

Sandra A. Brown, vice chancellor for research at UC San Diego, was a featured speaker at an October Congressional Briefing in Washington, D.C., where she shared important findings on adolescent neurodevelopment with other scientists and national leaders.

Selfies Reach New Heights with Wearable Drone

November 20, 2014 – 7:00 am | Edit Post

A team of developers that includes UC San Diego cognitive science alumna Jelena Jovanovic has won the $500,000 grand prize in Intel’s Make It Wearable challenge for their wrist-mounted drone. The device—named Nixie—can travel a fixed distance from its owner to take a photo or video of them, and then return. Images or video can instantly be shared with friends.

UC San Diego’s Brown Briefs Congress on Brain Development, Substance Use in Young

November 20, 2014 – 7:00 am | Edit Post

Sandra A. Brown, vice chancellor for research at UC San Diego, was a featured speaker at an October Congressional Briefing in Washington, D.C., where she shared important findings on adolescent neurodevelopment with other scientists and national leaders.

ViaCyte to Present at 26th Annual Piper Jaffray Healthcare Conference

November 20, 2014 – 7:00 am | Edit Post

SAN DIEGO, Nov. 20, 2014 /PRNewswire/ — ViaCyte, Inc., a privately-held regenerative medicine company developing a stem cell-derived islet replacement therapy for the treatment of diabetes, today announced that Dr. Paul Laikind, President and Chief Executive Officer, will present at the 26th Annual Piper Jaffray Healthcare Conference as follows:

Conference:

Tuesday, December 2, 2014

Time:

4:10 p.m. EST

Location:

The New York Palace, New York City

Dr. Laikind will review recent progress with the company’s VC-01™ islet replacement product candidate for the treatment of type 1 diabetes, which recently entered clinical phase testing.  A Phase 1/2 trial to assess safety, tolerability, and efficacy of the product in human subjects with diabetes was launched in September 2014, and the first implant was announced in October 2014. 

The presentation will be webcast live at the aforementioned time, and archived for viewing 90 days thereafter, via the Company’s website at www.viacyte.com, under the News and Events Section.

About ViaCyte  ViaCyte is a privately-held regenerative medicine company focused on developing a novel cell therapy for the treatment of diabetes.  ViaCyte’s lead product candidate, the VC-01 combination product, is based on the production of pancreatic progenitor cells derived from human pluripotent stem cells.  These progenitor cells are implanted in a durable and retrievable encapsulation device.  Once implanted and matured, these cells are designed to secrete insulin and other regulatory factors in response to blood glucose levels.  VC-01 is being developed as a potential long-term diabetes treatment without immune suppression, and without risk of hypoglycemia or other diabetes-related complications. 

ViaCyte is headquartered in San Diego, California with additional operations in Athens, Georgia.  The Company is funded in part by the California Institute for Regenerative Medicine and JDRF. 

Logo – http://photos.prnewswire.com/prnh/20121026/LA00871LOGO-a
SOURCE ViaCyte

ViaCyte to Present at 26th Annual Piper Jaffray Healthcare Conference

November 20, 2014 – 7:00 am | Edit Post

SAN DIEGO, Nov. 20, 2014 /PRNewswire/ — ViaCyte, Inc., a privately-held regenerative medicine company developing a stem cell-derived islet replacement therapy for the treatment of diabetes, today announced that Dr. Paul Laikind, President and Chief Executive Officer, will present at the 26th Annual Piper Jaffray Healthcare Conference as follows:

Conference:

Tuesday, December 2, 2014

Time:

4:10 p.m. EST

Location:

The New York Palace, New York City

Dr. Laikind will review recent progress with the company’s VC-01™ islet replacement product candidate for the treatment of type 1 diabetes, which recently entered clinical phase testing.  A Phase 1/2 trial to assess safety, tolerability, and efficacy of the product in human subjects with diabetes was launched in September 2014, and the first implant was announced in October 2014. 

The presentation will be webcast live at the aforementioned time, and archived for viewing 90 days thereafter, via the Company’s website at www.viacyte.com, under the News and Events Section.

About ViaCyte  ViaCyte is a privately-held regenerative medicine company focused on developing a novel cell therapy for the treatment of diabetes.  ViaCyte’s lead product candidate, the VC-01 combination product, is based on the production of pancreatic progenitor cells derived from human pluripotent stem cells.  These progenitor cells are implanted in a durable and retrievable encapsulation device.  Once implanted and matured, these cells are designed to secrete insulin and other regulatory factors in response to blood glucose levels.  VC-01 is being developed as a potential long-term diabetes treatment without immune suppression, and without risk of hypoglycemia or other diabetes-related complications. 

ViaCyte is headquartered in San Diego, California with additional operations in Athens, Georgia.  The Company is funded in part by the California Institute for Regenerative Medicine and JDRF. 

Logo – http://photos.prnewswire.com/prnh/20121026/LA00871LOGO-a
SOURCE ViaCyte