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Vuori and Ruoslahti were recently announced as Fellows of the NAI
NewGen Therapeutics Targeted Anti-Cancer Drug, NT-113, Demonstrates Compelling Activity in Glioblastoma Xenograft Models
MENLO PARK, Calif., Dec. 16, 2014 /PRNewswire/ – NewGen Therapeutics, Inc. today announced the publication of preclinical research strongly supporting NT-113, the company’s novel irreversible pan-erbB inhibitor (EGFR, HER2 and HER4), as a potential new treatment for glioblastoma multiforme (GBM), the most common and most aggressive malignant primary brain tumor in adults.
Researchers demonstrated that NT-113 was active against a variety of patient-derived GBM xenografts in which EGFR is amplified, overexpressed and/or expresses the disease-driving EGFRvIII mutation. In studies of intracranial mouse xenografts comparing NT-113 to the approved anticancer therapeutics lapatinib and/or erlotinib, NT-113 was associated with statistically significant improvement in survival. NT-113 both reduced tumor cell proliferation and induced apoptosis (controlled cell death). In previous pharmacokinetic studies, NT-113 demonstrated a long half-life and a high propensity to cross the blood brain barrier.
Researchers concluded that the pan-erbB inhibitory activity of NT-113 and downstream inhibition of Akt provide mechanistic rationale for its heightened anti-tumor activity. Excellent bio-distribution into the brain is also believed to contribute to the anti-GBM xenograft activity of NT-113. NT-113 was active in other GBM xenograft studies including one in which the cells are PTEN deficient, a known resistance mechanism for EGFR inhibitors, and another where cells overexpress both EGFR and HER2. Data support advancing NT-113 into clinical development for the treatment of erbB positive GBM, including patients with the disease driving EGFRvIII mutation.
The findings by NewGen and the company’s collaborators at Northwestern University and The University of California, San Francisco and the Mayo Clinic were published in the December 2014 issue of Molecular Cancer Therapeutics.
Harry D. Pedersen, NewGen Therapeutics President and Chief Executive Officer commented, “EGFR, HER2 and HER4 are part of the erbB family of tyrosine kinase receptors, and 90% of solid tumors have a mutation in at least one erbB receptor family member. By irreversibly inhibiting all family members we hope to shut down the individual receptors and the cooperative signaling between family members associated with resistance.”
NT-113 readily penetrates the blood brain barrier resulting in 4-8 times drug concentration in the brain relative to plasma. First-generation EGFR inhibitors like erlotinib and lapatinib are reversible and have very limited penetration of the central nervous system.
“GBM is a molecularly complex disease with significant unmet medical need: over 50% of patients have genetic alterations in EGFR or HER2,” Mr. Pedersen said. “These data provide a strong rationale for the clinical investigation of NT-113 in this patient population. We anticipate beginning clinical trials in early 2016.”
NT-113 is a potent oral irreversible pan-erbB inhibitor designed specifically to:
Target mutations in both the extracellular domain of EGFR (characteristic of GBM) and the intracellular domain of EGFR (characteristic of other tumours such as NSCLC),
Improve drug delivery into the brain to optimize drug delivery and treatment of patients with primary glioblastoma or brain metastases from an EGFR driven extracellular primary,
Overcome resistance to first generation erbB inhibitors by targeting redundancy in the pathway, and
Improve the efficacy of erbB-targeted therapies by irreversibly inhibiting multiple erbB receptors, and interfering with the cooperation that exists between receptors.About NewGen
NewGen Therapeutics is a privately held pharmaceutical company developing genetically targeted cancer drugs that are designed to overcome limitations of currently available therapies. The company’s pipeline includes multiple programs with novel small molecule drug leads against clinically important targets, each addressed to significant medical needs. NT-113, a potent irreversible pan-erbB inhibitor, is the company’s most advanced program and has demonstrated anti-cancer activity in several cancer xenograft studies, including glioblastoma, non-small cell lung, breast and gastric cancers. For more information, please visit our website at http://www.newgenther.com.
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SOURCE NewGen Therapeutics, Inc.
International Stem Cell Corporation Ranked as One of America’s Fastest Growing Companies by Deloitte
CARLSBAD, CA–(Marketwired – December 16, 2014) – International Stem Cell Corporation ( OTCQB : ISCO ), a California-based biotechnology company developing novel stem cell based therapies and biomedical products, announced that ISCO has been included in the 2014 Technology Fast 500T ranking of the fastest growing North American companies by Deloitte, one of the world’s largest and well-respected organizations providing audit, tax, consulting, and financial advisory services in more than 150 countries.
How’s this for strange? What’s likely the most important biotech patent battle of the decade is now being fought under outmoded rules that the U.S. Congress, in a rare spasm of common…
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Sorrento Therapeutics, Inc. Announces Strategic Investment By And Collaboration With Nantworks Founder Dr. Patrick Soon-Shiong For The Advancement Of Cancer ImmunotherapiesSAN DIEGO, Dec. 15, 2014 /PRNewswire/ –Sorrento Therapeutics, Inc. (NASDAQ: SRNE; Sorrento), an oncology…
SAN DIEGO, Dec. 16, 2014 (GLOBE NEWSWIRE) — Celladon Corporation (Nasdaq:CLDN), a clinical-stage biotechnology company with industry-leading expertise in the development of cardiovascular gene therapy, today announced that it has been added to the NASDAQ Biotechnology Index, through the annual update…
HedgePath Pharmaceuticals Receives IND Clearance To Commence Development Of Its Proposed Cancer Treatment
TAMPA, Fla. and SAN DIEGO, Dec. 16, 2014 /PRNewswire/ –HedgePath Pharmaceuticals, Inc. (OTCQB: HPPI), a clinical stage biopharmaceutical company that discovers, develops and plans to commercialize innovative therapeutics for patients with cancer, announced today that it received…
Is an experienced policymaker a more rational and a more self-interested bargainer than the average person? That is what nearly all prior research has assumed. But a new study from the University of California, San Diego shows just the opposite.
Company owned by Dr. Patrick Soon-Shiong to take 19.9 percent equity in Sorrento.
Double-stranded RNA required for mitosis, could be therapy target.