Principal Investigator – Downstream Processing | Thermo Fisher Scientific | San Diego

How will you make an impact?

The Science & Technology Team (STT) is passionate about developing end-to-end, standardized workflows and assays to support nucleic acid, viral vector, and cell therapy cGMP manufacturing. The Manager will build and lead a robust technical team proficient in downstream processes using robust platforms that ease the path towards GMP manufacturing. The motivated individual will lead viral vector downstream processing, scale-up, and continuous process improvements.

What will you do?

  • Utilize skills to implement end-to-end, robust downstream processing for Lab/pilot-scale and high-through-put viral vector preps
  • Lead planning, scheduling, and execution of experiments. Developing and executing filtration and chromatography separation methods for viral vector purification.
  • Direct and coordinate review of experiments, execution, data, and reporting of work completed; generate protocols and methods; address and resolve technical issues
  • Lead downstream process lab, delegate, and share lab management duties. Coordinate with technical operations and R&D to deliver project timelines. Evaluate and implement new methods, processes, techniques, and technology platforms
  • Hire, train, mentor and lead scientists and technicians involved in downstream viral processing. You will provide strong leadership, mentorship, and scientific oversight to internal team members.
  • Work in a matrix environment, interact externally and internally across technical teams, divisions, and functions; collaborate with clients, and support translational services

How will you get here?

Education

Ph.D. and post-doctoral experience in Biochemical Engineering, Microbiology, Biochemistry, Cell Biology, and/or molecular biology required with 2+ years or master’s degree with 7+years hands-on experience.

Experience

  • Technical proficiency in chromatographic separation and filtration techniques for AAV, Lentivirus purification process required. Experience working in a multi-disciplinary team with at least 2 years of supervisory experience.
  • Strong leadership skills in organization structure, team building, cross-functional communication, and accountability. Effective people management: ability to prioritize and lead through sophisticated processes/projects.

Knowledge, Skills, Abilities

  • Knowledge and hands on experience with downstream processing using HPLC, FPLC, membrane capture, filtration, resin/membrane chromatographic separation.
  • Hands-on experience with method development, SOP and test record development, some knowledge of cGMP requirements for biopharmaceutical manufacturing
  • Strong communication, receptive to suggestions and feedback, highly collaborative with the ability to adapt to change, work within a team to effect performance

NOTE: Position may require Covid-19 vaccination and/or routine testing, per client discretion. As a requirement to be onsite at Thermo Fisher Scientific this position requires vaccination status disclosure upon employment.

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