LA JOLLA?The most commonly prescribed antidepressants, selective serotonin reuptake inhibitors (SSRIs), lift the fog of depression for many people. But for around a third of people with major depressive disorder, SSRIs don?t make much of a difference. Now, researchers from the Salk Institute have pinned down a possible reason why?the neurons in at least some of these patients? brains may become hyperactive in the presence of the drugs. The study appeared in Molecular Psychiatry on January 30, 2019.