LA JOLLA—Dealing with an infection isn’t as straightforward as simply killing the pathogen. The body also needs to carefully steer and monitor its immune response to prevent collateral damage. This regulation, called disease tolerance, is crucial to protecting our tissues while the immune system tackles the infection head-on.
To survive an infection, your body must activate a tolerance mechanism that is compatible with the specific progression of your disease. So, if your body is changing over the course of your lifetime, does that mean the specific mechanisms it uses to survive an immune onslaught change, too?
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Credit: Jake Terry
Salk scientist Janelle Ayres, PhD, has spent the past two decades studying disease tolerance, and this question is…
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