- Highlights
- GLP-1 drugs have come to be thought of as “wonder drugs,” yet the mechanisms behind their many new health benefits have remained unclear
- New research from the Salk Institute reveals the mechanism behind one of these benefits: promoting pancreatic beta cells’ health and stress tolerance, long-term
- The findings show how GLP-1 drugs can trigger broad genomic responses
LA JOLLA—GLP-1s are building a reputation as “wonder drugs.” First characterized for their ability to improve insulin release and treat diabetes, the drugs were later found to promote weight loss and improve cardiovascular health. In addition to these surprising bonus benefits is the ability of GLP-1 drugs to improve pancreatic beta cell health. But how, exactly, are they doing that?
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