- Highlights
- Salk scientists discover that central nervous system-resident immune cells called microglia use TAM receptors (discovered by study senior author Greg Lemke in 1991) to eat specific nerve cells in mouse model of ALS
- The study is the first to show TAM receptors can be used to kill living nerve cells
- The insights contribute to ongoing efforts to harness TAM receptors in clinical settings to treat cancers, autoimmune disorders, and more
LA JOLLA—Amyotrophic lateral sclerosis (ALS) is a neurodegenerative disease that, according to the CDC, currently impacts around 35,000 Americans—with 5,000 more diagnosed each year. Risk climbs with age, and treatments only slow progression. With no cure and an aging population, scientists are urgently seeking insights that could change those devastating outcomes.
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