- Highlights
- Salk researchers establish microprotein atlas from human frontal cortex samples with and without Alzheimer’s disease, identifying more than 1,000 new microproteinsy
- The atlas reveals one microprotein that may contribute to age-related dysfunction in the brain’s resident immune cells
- The publicly available resource will allow scientists to consider microproteins in their studies, lighting the path to new potential targets for neurodegenerative diseases
- The study may also be used as a framework for building additional microprotein atlases for other tissues and disease areas
LA JOLLA—Scientists researching Alzheimer’s disease and neurodegeneration have been playing a difficult game. Their scientific playbook has been limited by the available resources that, while capturing loads of genes, proteins, and cells, have been missing something: microproteins.
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