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Highlights
- Salk scientists team up to create a comprehensive molecular atlas of exercise-associated changes in mice, capturing changes in gene expression, DNA methylation, metabolism, protein abundance, and more
- Atlas spans 22 tissues and finds distinct molecular responses to exercise across organs, cell types, sexes, and circadian phases
- Findings provide a reference for understanding how healthy tissues adapt to exercise and could inform personalized exercise strategies, identify targets for enhancing resilience, and guide future approaches to injury prevention
LA JOLLA—To understand what goes wrong in the body, scientists must first know what right looks like. Salk Institute researchers are building a scientific reference, piece by piece, for what makes a body healthy. Their latest effort maps how exercise reshapes the body at the molecular level, examining responses across organs, cell types, sexes, and circadian phases in mice.
The result is a first-of-its-kind molecular…
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