UC San Diego Launches ARPA-H Project to 3D Bioprint Patient-Specific Human Livers

Liver failure claims thousands of lives each year as patients in the United States wait for a donor organ. Now, a research project at the University of California San Diego, funded by the Advanced Research Projects Agency for Health (ARPA-H), aims to change that by developing a fully functional, patient-specific, 3D bioprinted liver. The project, which falls under ARPA-H’s Personalized Regenerative Immunocompetent Nanotechnology Tissue (PRINT) program, provides up to $25,771,771 for a 60-month period.

The multidisciplinary team has the goal of creating “made-to-order” livers grown from a patient’s own cells. The approach could offer a safe, scalable alternative to transplantation that eliminates the need for donor organs and lifelong immunosuppressant drugs.

“When people think about 3D printing, they often imagine making gadgets like cellphone holders or toys, not human organs,” said Shaochen Chen, PhD, professor in the Aiiso Yufeng Li Family Department of…
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