- Highlights
- Scientists discovered key genetic factors that determine whether a T cell acts as a powerful disease fighter or enters an ineffective, exhausted state.
- Turning off two transcription factors allowed exhausted T cells to regain their ability to kill tumors.
- The findings could help scientists engineer more powerful T cells for cellular therapies such as adoptive cell transfer (ACT) and CAR T cell therapy.
LA JOLLA—A multi-institutional study led by researchers at the Salk Institute for Biological Studies, UNC Lineberger Comprehensive Cancer Center, and UC San Diego has uncovered new genetic rules that determine how immune cells, known as CD8 “killer” T cells, choose between becoming long-lasting, protective defenders or slipping into exhausted, dysfunctional states. Turning off just two of these genes allowed exhausted T cells to regain their tumor-killing capacity.
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