A new study has uncovered new genetic rules that determine how CD8 “killer” T cells choose between becoming long-lasting, protective immune cells or slipping into exhausted, dysfunctional states. Turning off just two of these genes allowed exhausted T cells to regain their tumor-killing capacity.
The paper published in Nature titled, “Atlas-guided discovery of transcription factors for T-cell programming,” establishes a predictive framework to reprogram T cells to sustain immune memory while preserving their ability to fight cancer and infections, offering broad implications for cancer immunotherapy and infectious disease research.
The multi-institutional study was led by researchers at the Salk Institute for Biological Studies, UNC Lineberger Comprehensive Cancer Center, and UC San Diego.
CD8 T cells play a central role in the immune system by identifying and attacking virus-infected cells and cancer cells. However, during chronic infections or…
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