Antibiotic resistance has steadily accelerated in recent years to become a global health crisis with estimates of more than 10 million worldwide deaths per year by 2050. Antibiotic-resistant bacteria are known to flourish in hospital settings, sewage treatment areas, animal husbandry locations and fish farms.
In a new study published in npj Antimicrobials and Resistance titled, “A conjugal gene drive-like system efficiently suppresses antibiotic resistance in a bacterial population,” researchers from University of California, San Diego (UCSD) have developed a novel CRISPR-based technology for removing antibiotic resistant elements from populations of bacteria. The Pro-Active Genetics (Pro-AG) tool, named pPro-MobV, is a second-generation technology similar to gene drives, which are currently applied in insect populations to disrupt the spread of harmful properties, such as parasites that cause malaria.
“With pPro-MobV we have brought gene-drive thinking from insects to bacteria…
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