- Highlights
- The genome’s dynamic 3D shape influences the expression of very specific genes
- The protein NIPBL is a key facilitator of genome structures that inform cell identity
- Findings may inform new therapeutics for disorders related to dysfunctional genome folding, including some cancers and developmental disorders such as autism-related disorders
LA JOLLA—How does our DNA store the massive amount of information needed to build a human being? And what happens when it’s stored incorrectly? Jesse Dixon, MD, PhD, has spent years studying the way this genome is folded in 3D space—knowing that dysfunctional folding can cause cancers and developmental disorders, including autism-related disorders. The latest research from his lab adds to a growing understanding that the genome’s 3D organization is constantly in flux. Using different types of human cells, his lab showed that this dynamic genome unfolding and refolding process occurs at different…
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