How do plants survive constant DNA damage?

  • Highlights
  • Researchers identify YAF9B as a protein activated by DNA damage, acting like an emergency responder to life-threatening genetic alterations in plant tissues containing stem cells
  • Study reveals how plants leverage specific genomic signals to accurately repair dangerous DNA breaks
  • Findings could help improve precision genome editing and crop resilience

LA JOLLA—Similar to the way DNA damage can contribute to human diseases like cancer, it can also disrupt growth, development, and survival in plants. Every day, plants endure environmental stresses like sunlight, radiation, drought, and soil stress—all of which can damage their DNA. However, they cannot move away from danger. How do plants handle all that damage?

Plants rely on powerful repair systems that constantly monitor and fix their genomes. But how plants coordinate these repairs—especially in the stem-cell-like tissues responsible for future growth—has remained poorly understood.

Now, Salk Institute scientists have discovered a…
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