- Highlights
- Salk scientists explore long-standing mystery of why iron that builds up in neuronal cells becomes harmful over time in neurodegenerative diseases like Alzheimer’s and Parkinson’s
- They find a new cellular process, named chronoferroptosis, wherein chronic iron dysregulation in neurons makes them more vulnerable to stressors
- The study complements other ongoing research at Salk to design compounds that inhibit this pathway, and could be a promising future avenue for creating therapies that boost resilience in aging brains
LA JOLLA—Neurodegenerative diseases affect tens of millions of people worldwide. Among these, Alzheimer’s and Parkinson’s diseases are the most common; in the United States alone, the Alzheimer’s Disease Association and Parkinson’s Foundation report roughly 7 million people with Alzheimer’s and another million with Parkinson’s. An intriguing clue lies in the tangled mystery of neurodegeneration that scientists are working to solve: iron accumulation.
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