Isolation drives alcohol consumption through brain circuit that differs by sex

  • Highlights
  • Salk study pinpoints a pathway between two brain regions responsible for driving social isolation-related alcohol consumption in mice
  • The same pathway has opposing outcomes in male and female mice—activating that pathway increases alcohol consumption in male mice but decreases it in females
  • Findings may be used to improve risk assessment and treatment strategies for alcohol use disorder, and highlight the importance of sex as a key variable in designing optimal therapies and interventions

LA JOLLA—The COVID-19 pandemic tested us in many ways—how we handle crisis, isolation, health, loss, and so much more. Amidst all the conversations about how we cope, one topic came up again and again: alcohol.

Reesha Patel (left) and Kay Tye (right) identified a pathway between two brain regions that increases alcohol consumption after social isolation in male mice... <br /><a href=Click here to view original post

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