- Highlights
- Salk scientists and collaborators publish the first single-cell atlas to simultaneously map 3D genome architecture and DNA methylation across the human body—86,689 cells spanning 16 tissues, 35 major cell types, and 206 subtypes
- The atlas pinpoints cell types where epigenetic features overlap with genetic risk for conditions including atrial fibrillation, bipolar disorder, schizophrenia, and blood-glucose regulation, helping explain how non-coding DNA variants may contribute to disease
- All data are freely available through an interactive browser, providing a reference for gene-regulation research and a training resource for AI models that predict the impact of genetic variants
LA JOLLA—Every cell in the human body carries the same three billion letters of DNA, yet a neuron, a heart muscle cell, and a pancreatic beta cell each use that shared code to do entirely different jobs. How cells pull off this trick comes down to epigenetics—chemical tags…
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